Adding a tune to your vehicle automatically puts it in the Severe Service or Special Operating Conditions category. If you maintain according to that schedule, longevity should not be much affected. If you tend to put off repairs, extend oil change intervals, AND expect to keep your vehicle for a good length of time, a tune is NOT for you. Speaking generally of course
But yeah, step up the maintenance, use quality fluids (oil/gas/etc), and you should be fine.